HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 22936266, compound → HCID 22936256, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 22936266 | HCID 22936266 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | HCID 22936256 | HCID 22936256 | 37.6% |
Reaction Steps
After dissolving N-[4-(6-aminomethyl-7-methoxy-quinolin-4-yloxy)phenyl]-N′-phenylurea trifluoroacetate (40 mg) in pyridine (1.0 ml) and acetic anhydride (1.0 ml), the solution was stirred overnight at room temperature. The reaction solution was concentrated under reduced pressure and the obtained crude product was crystallized with ethyl acetate to obtain the title compound (13 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08372981B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-f7d826f3111b42bca8a5bd1638c83050 |
| Source note | uspto-grants-2013_02 |