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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 387942Generated: October 31, 2026

HCID 22936266, compound → HCID 22936256, compound

https://huagongshe.com/reaction/387942

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 22936266HCID 22936266—
SolventPyridineHCID 1049—
SolventAcetic AnhydrideHCID 7918—
ProductHCID 22936256HCID 2293625637.6%

Reaction Steps

After dissolving N-[4-(6-aminomethyl-7-methoxy-quinolin-4-yloxy)phenyl]-N′-phenylurea trifluoroacetate (40 mg) in pyridine (1.0 ml) and acetic anhydride (1.0 ml), the solution was stirred overnight at room temperature. The reaction solution was concentrated under reduced pressure and the obtained crude product was crystallized with ethyl acetate to obtain the title compound (13 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08372981B2
Source datasetuspto-grants-2013_02
ORD IDord-f7d826f3111b42bca8a5bd1638c83050
Source noteuspto-grants-2013_02