HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 387951Generated: October 31, 2026
Pyrrolidine → N-{4-[6-Cyano-7-(2-hydroxy-3-(pyrrolidin-1-yl)propoxy)quinolin-4-yloxy]-2-fluorophenyl)-N'-(thiazol-2-yl)urea
https://huagongshe.com/reaction/387951
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | N-[4-(6-Cyano-7-oxiranylmethoxyquinolin-4-yloxy)-2-fluorophenyl]-N'-(thiazol-2-yl)urea | HCID 22936623 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-{4-[6-Cyano-7-(2-hydroxy-3-(pyrrolidin-1-yl)propoxy)quinolin-4-yloxy]-2-fluorophenyl)-N'-(thiazol-2-yl)urea | HCID 86591470 | — |
Reaction Steps
After adding tetrahydrofuran (1 ml) and pyrrolidine (0.1 ml) to N-[4-(6-cyano-7-oxiranylmethoxy-quinolin-4-yloxy)-2-fluorophenyl]-N′-(thiazol-2-yl)urea (120 mg), the mixture was heated at 50° C. for 40 minutes. The reaction solution was purified by NH silica gel column chromatography (ethyl acetate-methanol system) to obtain the title compound (70 mg) as light yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08372981B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-cd2feb72e7e64d32b78c46b200b5c8f7 |
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| Source note | uspto-grants-2013_02 |
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