HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 387952Generated: October 30, 2026
Dimethyl Sulfoxide → N-[4-(6-Cyano-7-oxiranylmethoxyquinolin-4-yloxy)-2-fluorophenyl]-N'-(thiazol-2-yl)urea
https://huagongshe.com/reaction/387952
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | phenyl N-(1,3-thiazol-2-yl)carbamate | HCID 651148 | — |
| Reactant | 4-(4-Amino-3-fluorophenoxy)-7-oxiranylmethoxyquinoline-6-carbonitrile | HCID 22936249 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[4-(6-Cyano-7-oxiranylmethoxyquinolin-4-yloxy)-2-fluorophenyl]-N'-(thiazol-2-yl)urea | HCID 22936623 | 11.8% |
Reaction Steps
After adding dimethylsulfoxide (1 ml) and phenyl N-(2-thiazolyl)carbamate (94 mg) to 4-(4-amino-3-fluorophenoxy)-7-oxiranylmethoxyquinoline-6-carbonitrile (100 mg), the mixture was heated at 80° C. for 90 minutes. Water was added and the precipitated crystals were filtered out to obtain the title compound (16 mg) as light yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08372981B2 |
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| Source dataset | uspto-grants-2013_02 |
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| ORD ID | ord-bcb77e86528243bf8484cb325b06be20 |
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| Source note | uspto-grants-2013_02 |
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