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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 387971Generated: October 29, 2026

Toluene → HCID 58931434, compound

https://huagongshe.com/reaction/387971

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTolueneHCID 1140—
Reactant4-Fluorophenyl isocyanateHCID 70955—
ReactantHCID 58931477HCID 58931477—
SolventAcetonitrileHCID 6342—
ProductHCID 58931434HCID 58931434—

Reaction Steps

After adding toluene (1 ml), acetonitrile (0.5 ml) and 4-fluorophenyl isocyanate (0.03 ml) to 4-(6-phenyl-furo[2,3-d]pyrimidin-4-yloxy)phenylamine (40 mg), the mixture was heated to reflux for 30 minutes. After cooling, the precipitated crystals were filtered out and washed with toluene to obtain the title compound (42 mg) as light yellow crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08372981B2
Source datasetuspto-grants-2013_02
ORD IDord-8f9b87f6e9184260ba30be342a7b9b86
Source noteuspto-grants-2013_02