HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 86591477, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Thioanisole | HCID 7520 | — |
| Reactant | HCID 22936750 | HCID 22936750 | — |
| Product | HCID 86591477 | HCID 86591477 | — |
Reaction Steps
1-(4-(7-Benzyloxy-6-cyanoquinolin-4-yloxy)-2-chloro-phenyl)-3-ethylurea (1 g) was treated with trifluoroacetic acid and thioanisole for deprotection in the same manner as Production Example 21, and the obtained hydroxy compound (0.48 g) was treated in the same manner as Example 543 to obtain the title compound (0.31 g) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08372981B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-21da625f13a64ac1b1c681bc1a39801f |
| Source note | uspto-grants-2013_02 |