反应详情

After dissolving 65 mg of N-cyclopropyl-N′-(4-(6-(4-(2-diethylaminoethoxy)-phenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)-2-fluorophenyl)urea in 2 ml of tetrahydrofuran, there was added dropwise 0.5 ml of tetrabutylammonium fluoride (1M tetrahydrofuran solution) and the mixture was refluxed for 3 hours. After returning it to room temperature, water was added, the mixture was stirred, and the precipitated crystals were filtered out, washed with water and ether-hexane (1:1) and dried under reduced pressure to obtain 25 mg of the title compound.

1. temperaturethe mixture was refluxed for 3 hours
2. customto room temperature
3. filtrationthe precipitated crystals were filtered out
4. washwashed with water and ether-hexane (1:1)
5. customdried under reduced pressure