HRID388062

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID651148

phenyl N-(1,3-thiazol-2-yl)carbamate

C10H8N2O2S

结构：CC(C)(C)OC(=O)N1CCC(COc2cc3nccc(Oc4ccc(N)cc4)c3cc2C#N)CC1

HCID67202924

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCC(COc2cc3nccc(Oc4ccc(NC(=O)Nc5nccs5)cc4)c3cc2C#N)CC1

HCID86591482

4-{6-Cyano-4-[4-(3-thiazol-2-ylureido)phenoxy]quinolin-7-yloxymethyl}piperidine-1-carboxylic acid tert-butyl ester

C31H32N6O5S

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

4-(4-(4-Aminophenoxy)-6-cyanoquinolin-7-yloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (225 mg) was heated in dimethylsulfoxide together with thiazol-2-yl-carbamic acid phenyl ester at 80° C. in the same manner as Example 713 to obtain the title compound (240 mg) as a solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7a101099c756455bb10181cd5dbea6c8
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08372981B2
来源说明: uspto-grants-2013_02

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][C:16]2[CH:25]=[C:24]3[C:19]([C:20]([O:26][C:27]4[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][CH:28]=4)=[CH:21][CH:22]=[N:23]3)=[CH:18][C:17]=2[C:34]#[N:35])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C1([O:42][C:43](=O)[NH:44][C:45]2[S:46][CH:47]=[CH:48][N:49]=2)C=CC=CC=1>CS(C)=O>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][C:16]2[CH:25]=[C:24]3[C:19]([C:20]([O:26][C:27]4[CH:32]=[CH:31][C:30]([NH:33][C:43]([NH:44][C:45]5[S:46][CH:47]=[CH:48][N:49]=5)=[O:42])=[CH:29][CH:28]=4)=[CH:21][CH:22]=[N:23]3)=[CH:18][C:17]=2[C:34]#[N:35])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]