Potassium Phosphate, Tribasic → HCID 24985363, compound

Participants

Reaction Conditions

Reaction Steps

3-(6-(2-Methoxyphenylamino)-5-nitropyridin-2-yl)phenol. 6-Chloro-N-(2-methoxy-phenyl)-3-nitropyridin-2-amine (2.03 g, 7.27 mmol), 3-hydroxyphenylboronic acid (1.50 g, 10.90 mmol), palladium (II) acetate (0.489 g, 0.727 mmol), 1,1′-(bis(di-tertbutyl)phosphine)ferrocene (0.344 g, 0.727 mmol) and potassium phosphate (4.62 g, 21.81 mmol) were combined in dioxane and heated to 98° C. under nitrogen conditions for 16 h. Upon consumption consumption of starting material (monitored by TLC), the reaction mixture was filtered through celite. The filtrate was condensed under reduced pressure to afford the crude product. The crude material was purified using Biotage silica gel chromatography (10-40% ethyl acetate in hexanes) to afford the title compound (1.48 g, 59%). MS (ESI) m/z 338.4 [M+1]+.

Provenance & Evidence