1-Butanol → HCID 136282915, compound

Participants

Role	Name	HCID	Charge
Reactant	1-Butanol	HCID 263	—
Reactant	1-(3-Aminopropyl)-2-pyrrolidinone	HCID 82111	—
Reactant	2-Amino-3,5-dibromopyrazine	HCID 620004	—
Reactant	HCID 86626398	HCID 86626398	—
Product	HCID 136282915	HCID 136282915	80%

Reaction Steps

1-(3-(3-Amino-6-bromopyrazin-2-ylamino)propyl)pyrrolidin-2-one. 3,5-Dibromo-pyrazin-2-amine (253 mg, 1 mmol), 1-(3-aminopropyl)pyrrolidin-2-one (426 mg, 1 mmol), and n-butanol (2 mL) were stirred at 100° C. under nitrogen for 3 d. The reaction was purified on silica gel column (0-100% ethyl acetate in hexanes) to give the title compound (250 mg, 80% yield) as a white solid. MS (ESI) m/z 315.9 [M+1]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08372976B2
Source dataset	uspto-grants-2013_02
ORD ID	ord-d90e48c3c1fd4bf7af9afd8bfce43667
Source note	uspto-grants-2013_02