Potassium Carbonate → HCID 66699704, compound

Participants

Reaction Conditions

Reaction Steps

(R)-3-Nitro-N-(1-phenylethyl)-6-(quinolin-5-yl)pyridin-2-amine. To a solution of (R)-6-chloro-3-nitro-N-(1-phenylethyl)pyridin-2-amine (1.12 g, 4.03 mmol) and quinolin-5-ylboronic acid (0.91 g, 5.24 mmol) in DMF (75 mL) was added potassium carbonate (2.23 g, 16.1 mmol) in water (25 mL). The reaction solution was purged with a stream of nitrogen followed by the addition of tetrakis(triphenylphosphine)palladium(0) (0.466 g, 0.403 mmol). After heating at 85° C. for 2 h, the solvent was removed under reduced pressure. The crude product was purified by silica gel chromatography to afford the title compound (1.1 g, 74% yield). MS (ESI) m/z 371.3 [M+1]+.

Provenance & Evidence