Potassium Carbonate → HCID 24985020, compound

Participants

Reaction Conditions

Reaction Steps

(S)-2-(6-(5-Isopropyl-2-methoxyphenyl)-3-nitropyridin-2-ylamino)-3-methylbutan-1-ol. To a solution of (S)-2-(6-Chloro-3-nitropyridin-2-ylamino)-3-methylbutan-1-ol (0.80 g, 3.08 mmol) and 5-isopropyl-2-methoxyphenylboronic acid (0.78 g, 4.00 mmol) in DMF (50 mL) was added potassium carbonate (1.7 g, 12.3 mmol) in water (8 mL). The reaction solution was purged with a stream of nitrogen followed by the addition of tetrakis(triphenylphosphine) palladium(0) (0.358 g, 0.308 mmol). After heating at 85° C. for 2 h, the solvent was removed under reduced pressure. The crude product was purified by silica gel chromatography to afford the title compound (1.11 g, 96% yield). MS (ESI) m/z 374.3 [M+1]+.

Provenance & Evidence