Chlorpheniramine Maleate → Chlorpheniramine

HRID 388180Notes

Reaction equation

HRID 388180 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][CH:6]([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][N:19]=1)[C:7]1[CH:8]=[CH:9][C:10]([Cl:13])=[CH:11][CH:12]=1)[CH3:3].C(/C(O)=O)=C/C(O)=O>O>[CH3:1][N:2]([CH2:4][CH2:5][CH:6]([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][N:19]=1)[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)[CH3:3]

Participants

3

Reactant 1

HCID 5281068Chlorpheniramine Maleate

Product 1

HCID 2725Chlorpheniramine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Chlorpheniramine polistirex was prepared by mixing 3.12 kg of chlorpheniramine maleate with 26.00 kg of ion-exchange resin particles (AMBERLITE IRP69; US Std. Mesh #100-#400) suspended in USP water at about 30° C. The resulting suspension was centrifuged and the product washed with USP water. The wet cake was dried and sieved through a US Std #30 mesh screen. The chlorpheniramine content of the dried product was equivalent to approximately 11% by weight.

Workup

  1. washthe product washed with USP water
  2. customThe wet cake was dried
  3. filtrationsieved through a US Std #30 mesh screen

Sources & evidence

ORD record
ord-d25a0628bf3642a9a7909ac378056511
Source dataset
uspto-grants-2013_02
Patent number
US08377480B2

Reaction notes

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