Dimethylamine → HCID 44608333, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of Wogonin (28.4 g), methanol (350 ml), 37% formaldehyde solution (8.1 ml), 33% dimethylamine solution (13.6 g) was stirred under for 4 hours at 55° C., then precipitates were removed by filtration and washed several times with methanol, after drying under reduced pressure at 65° C. to get the product as yellow solid 32.7 g of purity 99.3%. MS: (API-ES) m/z 342.5[M+H]+; 1H NMR (DMSO-d6, 400 MHz) δ 8.03˜8.04 (m, 2H, Ar-2′,6′-H), 7.59-7.60 (m, 3H, Ar-3′,4′,5′-H), 6.81 (s, 1H, 3-H), 3.97 (s, 2H, CH2), 3.82 (s, 3H, 8-OCH3), 2.56 (s, 6H, CH3).

Provenance & Evidence