Formaldehyde → HCID 44608334, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of Wogonin (28.4 g), methanol (350 ml), 37% formaldehyde solution (8.1 ml), pyrrolidine (7.1 g) was stirred under for 4 hours at 55° C., then precipitates were removed by filtration and washed several times with methanol, after drying under reduced pressure at 65° C. to get the product as orange red solid 35.4 g of purity 99.1%. MS: (API-ES) m/z 368.5[M+H]+, 390.5[M+Na]+; 1H NMR (DMSO-d6, 400 MHz) δ 8.03˜8.04 (m, 2H, Ar-2′,6′-H), 7.59˜7.60 (m, 3H, Ar-3′,4′,5′-H), 6.79 (s, 1H, 3-H), 4.09 (s, 2H, CH2), 3.81 (s, 3H, 8-OCH3), 3.03 (s, 4H, CH2), 1.90 (s, 4H, CH2).

Provenance & Evidence