Formaldehyde → HCID 44608336, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of Wogonin (28.4 g), methanol (350 ml), 37% formaldehyde solution (8.1 ml), morpholine (8.7 g) was stirred under for 4 hours at 55° C., then precipitates were removed by filtration and washed several times with methanol, after drying under reduced pressure at 65° C. to get the product as yellow solid 36.3 g of purity 99.1%. MS: (API-ES) m/z 384.5[M+H]+, 406.5[M+Na]+; 1H NMR (DMSO-d6, 400 MHz) δ 8.07˜8.08 (m, 2H, Ar-2′,6′-H), 7.61˜7.63 (m, 3H, Ar-3′,4′,5′-H), 7.00 (s, 1H, 3-H), 3.87 (s, 3H, 8-OCH3), 3.82 (s, 2H, CH2), 3.65 (s, 4H, CH2), 2.60 (s, 4H, CH2).

Provenance & Evidence