Triphenylphosphine → HCID 66718925, compound

Participants

Reaction Steps

To 55 mL of a tetrahydrofuran solution containing 0.39 g (2.40 mmol) of 2-(imidazo[1,2-a]pyrimidin-2-yl)ethanol obtained in Example 1-(b) were added 0.69 g (2.00 mmol) of ethyl 8-hydroxy-3-oxo-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-4-acetate (see WO 98/14192 A) and 0.74 g (2.80 mmol) of triphenyl-phosphine, and the mixture was stirred under ice-cooling. Then, 2.6 mL of a tetra-hydrofuran solution containing 0.53 g (2.60 mmol) of diisopropyl azodicarboxylate was added dropwise to the mixture over 3 minutes, the mixture was gradually elevated to room temperature, and stirred for 14 hours.

Provenance & Evidence