Ethanol hydrochloride → HCID 136377303, compound

HRID 388229Notes

Reaction equation

HRID 388229 reaction equation
[N:1]1[C:2]([CH2:10][CH2:11][O:12][C:13]2[CH:35]=[CH:34][C:16]3[CH2:17][CH:18]([CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[C:19](=[O:27])[N:20]([CH2:22][C:23]([F:26])([F:25])[F:24])[CH2:21][C:15]=3[CH:14]=2)=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[N:6][C:5]=12.[ClH:36].C(O)C>[C].[Pd].C(O)C>[ClH:36].[O:27]=[C:19]1[CH:18]([CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH2:17][C:16]2[CH:34]=[CH:35][C:13]([O:12][CH2:11][CH2:10][C:2]3[N:1]=[C:5]4[NH:6][CH2:7][CH2:8][CH2:9][N:4]4[CH:3]=3)=[CH:14][C:15]=2[CH2:21][N:20]1[CH2:22][C:23]([F:26])([F:25])[F:24]

Participants

5

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 66718925HCID 66718925, compound

Product 1

HCID 136377303HCID 136377303, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To 11 mL of an ethanol solution containing 0.28 g (0.57 mmol) of ethyl 8-[2-(imidazo[1,2-a]pyrimidin-2-yl)ethoxy]-3-oxo-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetra-hydro-1H-2-benzazepin-4-acetate obtained in Example 1-(c) were added 5.5 mL of 3.2M hydrogen chloride/ethanol solution and 0.14 g of 10% palladium carbon, and the mixture was stirred under hydrogen atmosphere at room temperature for 1 hour.

Sources & evidence

ORD record
ord-1c9c6ef19efe479a8c4021f79e5cea12
Source dataset
uspto-grants-2013_02
Patent number
US08377922B2

Reaction notes

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