1,4-Dioxane hydrochloride → HCID 136377313, compound

HRID 388236Notes

Reaction equation

HRID 388236 reaction equation
[O:1]=[C:2]1[C@H:8]([CH2:9][C:10]([O:12][CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[O:11])[CH2:7][C:6]2[CH:21]=[CH:22][C:23]([O:25][CH2:26][CH2:27][C:28]3[N:29]=[C:30]4[N:35](C(OC(C)(C)C)=O)[CH2:34][CH2:33][CH2:32][N:31]4[CH:43]=3)=[CH:24][C:5]=2[CH2:4][N:3]1[CH2:44][C:45]([F:48])([F:47])[F:46].[ClH:49].O1CCOCC1>ClCCl>[ClH:49].[O:1]=[C:2]1[C@H:8]([CH2:9][C:10]([O:12][CH2:13][CH2:14][N:15]2[CH2:16][CH2:17][O:18][CH2:19][CH2:20]2)=[O:11])[CH2:7][C:6]2[CH:21]=[CH:22][C:23]([O:25][CH2:26][CH2:27][C:28]3[N:29]=[C:30]4[NH:35][CH2:34][CH2:33][CH2:32][N:31]4[CH:43]=3)=[CH:24][C:5]=2[CH2:4][N:3]1[CH2:44][C:45]([F:47])([F:48])[F:46]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86646171HCID 86646171, compound

Product 1

HCID 136377313HCID 136377313, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 1 mL of a dichloromethane solution containing 71.7 mg (0.105 mmol) of [2-(morpholin-4-yl)]ethyl(4S)-3-oxo-8-[2-(8-tert-butoxycarbonyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidin-2-yl)ethoxy]-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepin-4-acetate obtained in Example 10-(a) was added 2.00 mL (8.00 mmol) of 4N hydrogen chloride/1,4-dioxane solution, and the resulting mixture was stirred under nitrogen gas atmosphere at room temperature for 12 hours.

Sources & evidence

ORD record
ord-9eecc80348874e829d85670caabe936c
Source dataset
uspto-grants-2013_02
Patent number
US08377922B2

Reaction notes

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