3,4,5-Trimethoxybenzaldehyde → HCID 44633462, compound

Participants

Reaction Steps

In a round-bottom glass flask equipped with a magnetic stir bar 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methoxyacetohydrazide (1 eq., 1.1 mmol; 260 mg) was dissolved in ethanol (10 mL) at room temperature. To this well stirred solution, acetic acid (˜3 drops) and 3,4,5-trimethoxy-benzaldehyde (1.2 eq, 1.3 mmol; 260 mg) were added, and the reaction mixture was heated for 12 hours. The mixture was then cooled and the crude product was diluted with Et2O and filtered and the solid was washed thoroughly with Et2O to yield: 300 mg (65%) of (2-1).

Provenance & Evidence