Tert-butyl 1,4-diazepane-1-carboxylate → HCID 22557290, compound

HRID 388287Notes

Reaction equation

HRID 388287 reaction equation
C(OC([N:8]1[CH2:14][CH2:13]C[NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.[C:15]1([S:21]([N:24]2[C:29]3[CH:30]=[C:31]([Cl:35])[CH:32]=[C:33](Br)[C:28]=3[O:27][CH2:26][CH2:25]2)(=[O:23])=[O:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.BrC1C2OCCN(S(C3C=CC=C(Cl)C=3)(=O)=O)C=2C=CC=1>>[C:15]1([S:21]([N:24]2[C:29]3[CH:30]=[C:31]([Cl:35])[CH:32]=[C:33]([N:8]4[CH2:9][CH2:10][NH:11][CH2:13][CH2:14]4)[C:28]=3[O:27][CH2:26][CH2:25]2)(=[O:23])=[O:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 2756058Tert-butyl 1,4-diazepane-1-carboxylateHCID 22557215HCID 22557215, compoundHCID 22557246HCID 22557246, compound

Product 1

HCID 22557290HCID 22557290, compound

Procedure

Similarly, but replacing piperazine-1-carboxylic acid tert-butyl ester with [1,4]diazepane-1-carboxylic acid tert-butyl ester and 4-benzenesulfonyl-8-bromo-6-chloro-3,4-dihydro-2H-benzo[1,4]oxazine with 8-bromo-4-(3-chloro-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine the following compound was prepared:

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-cceed78214ea4099b689e2b8b2dc37e4
Source dataset
uspto-grants-2013_02
Patent number
US08377931B2

Reaction notes

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