反应详情

温度

110 °C

6-Bromo-1-methyl-4-(1H-tetrazol-5-yl)-1H-indazole (604.6 mg, 2.166 mmol) was dissolved in chloroform (20 ml). Chloroacetyl chloride (0.520 ml, 6.49 mmol) was added and the mixture stirred at 110° C. for 46 h. Further chloroacetyl chloride (0.174 ml, 2.166 mmol) was added and the reaction continued stirred at 110° C. for 26 h. The reaction mixture was cooled and the solvent removed in vacuo. The resultant white solid was washed with DCM, the solvent removed under vacuum and the solid dried under high vacuum for 18 h to give the title compound as a white solid (528 mg).

1. stirringthe reaction continued stirred at 110° C. for 26 h
2. temperatureThe reaction mixture was cooled
3. customthe solvent removed in vacuo
4. washThe resultant white solid was washed with DCM
5. customthe solvent removed under vacuum
6. customthe solid dried under high vacuum for 18 h