Diisopropylethylamine → HCID 178522773, compound

Participants

Reaction Steps

To a solution of HATU (0.200 mmol) in DMF (0.5 ml) was added 4-(1H-pyrazol-3-yl)benzoic acid (Apollo Scientific Ltd.) (0.12 mmol) in DMF (0.5 ml), followed by DIPEA (0.300 mmol) and finally {[2-(trifluoromethyl)-1H-indol-5-yl]methyl}amine (Intermediate 4, 0.025 g, 100 μmol) in DMF (0.25 ml). The experiment was carried out in an array form using a Bohdan mini block. The block was shaken for 24 hours. The compound was purified using an amino propyl column which was pre-conditioned with DMF. The column was washed with DMF (×2). The washings were evaporated to dryness and the resulting residue was then purified by MDAP to give the title compound;

Provenance & Evidence