Ethanol → HCID 86633294, compound

HRID 388404Notes

Reaction equation

HRID 388404 reaction equation
Cl[C:2]1[C:3]2[C:19]([CH3:20])=[C:18]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[S:17][C:4]=2[N:5]=[C:6]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[N:7]=1.NC(N)=[S:28].C(O)C>O>[Cl:16][C:11]1[CH:10]=[C:9]([CH:14]=[CH:13][C:12]=1[Cl:15])[CH2:8][C:6]1[NH:7][C:2](=[S:28])[C:3]2[C:19]([CH3:20])=[C:18]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[S:17][C:4]=2[N:5]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 2723790ThioureaHCID 86633293HCID 86633293, compound

Product 1

HCID 86633294HCID 86633294, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1.23 g of ethyl 4-chloro-2-(3,4-dichlorobenzyl)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate, 594 mg of thiourea and 50 mL of ethanol was stirred at room temperature for 35 hours. Then 50 mL of water was added, followed by 30 minutes' stirring. Crystals were recovered by filtration and washed with water. Drying the same under aeration, 1.15 g of the title compound was obtained.

Workup

  1. waitfollowed by 30 minutes
  2. stirring' stirring
  3. filtrationCrystals were recovered by filtration
  4. washwashed with water
  5. customDrying the same under aeration

Sources & evidence

ORD record
ord-e7521ece00b64768af7af3ecc221034d
Source dataset
uspto-grants-2013_02
Patent number
US08377944B2

Reaction notes

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