HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butanol → 1,1-Dimethylethyl 3-(4-chlorophenyl)-4-isothiazolecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | HCID 12437453 | HCID 12437453 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1,1-Dimethylethyl 3-(4-chlorophenyl)-4-isothiazolecarboxylate | HCID 58432986 | — |
Reaction Steps
To a mixture of 7 (3.35 g), DMAP (1.7 g) and tBuOH (5.2 g) in CH2Cl2 (50 ml) is added 3.2 g of EDCI and the clear solution is stirred over the weekend. Additional CH2Cl2 (100 ml) is added and the mixture is washed with 1N HCl (2×150 ml), sat. NaHCO3 (150 ml), brine (150 ml), dried and concentrated. This afforded 3.75 g of 8 as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08377953B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-67fd5616b4144d0ca26758dc4ccd024f |
| Source note | uspto-grants-2013_02 |