3-Bromopyridine → HCID 25135290, compound

Participants

Reaction Steps

A solution of 3-bromopyridine (103 mg) in 2.5 ml of ether is cooled to −78° C. under N2 and to this is added drop-wise a BuLi solution (0.375 ml, 1.6 M in hex). After stirring for 15 min, a solution of 15 (150 mg) in THF is added drop-wise. Stirring is continued for 20 min at −78° C., the red colored reaction mixture is quenched with water (5 ml) and the cooling bath is removed. Water (25 ml) and EtOAc (30 ml) are added. After washing, the layers are separated, the organic layer is washed with brine, dried and concentrated to afford an orange foam (200 mg). The material is purified by flash column chromatography (2% MeOH in CH2Cl2). Desired compound 16 is obtained as white foam showing the expected mass in LCMS (M+1:379 and its isotopes at 380; 381 and 382).

Provenance & Evidence