Potassium Carbonate → 1-(1,4-Dimethyl-1H-indol-3-ylmethyl)-3-(2-morpholin-4-yl-ethyl)-1H-quinazoline-2,4-dione

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	((1,4-Dimethylindole-3-yl)methyl)trimethylammonium iodide	HCID 17836486	—
Reactant	3-[1-(4-chloro-phenyl)-ethyl]-1H-quinazoline-2,4-dione	HCID 68743777	—
Solvent	Dimethylformamide	HCID 6228	—
Product	1-(1,4-Dimethyl-1H-indol-3-ylmethyl)-3-(2-morpholin-4-yl-ethyl)-1H-quinazoline-2,4-dione	HCID 68750340	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

To a mixture of 3-[1-(4-chloro-phenyl)-ethyl]-1H-quinazoline-2,4-dione (175 mg, 0.58 mmol) and (1,4-dimethyl-1H-indol-3-ylmethyl)-trimethylammonium iodide (210 mg, 0.61 mmol) in DMF (2.5 mL) is added K2CO3 (100 mg, 0.72 mmol). The mixture is stirred at 60° C. for 4 hours.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08377949B2
Source dataset	uspto-grants-2013_02
ORD ID	ord-d8a4fd6df22b49cfa3b27c206d299f0b
Source note	uspto-grants-2013_02