Water → HCID 131730215, compound

Participants

Reaction Steps

After suspending N-(2-fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide (31.7 mg) in ethanol (0.317 ml)-water (0.0058 ml), 2.5 M sulfuric acid (0.010 ml) was added at room temperature to form a solution. The solution was stirred overnight at room temperature. The precipitate was collected by filtration and washed with ethanol (0.158 ml, 2 times). It was then dried under aeration at room temperature for 30 minutes, and then dried with warm air at 60° C. for 1 day to give the title compound (26.5 mg) as white powder.

Provenance & Evidence