Water → HCID 131730216, compound

Participants

Reaction Conditions

Reaction Steps

After suspending N-(2-fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide (65.3 mg) in 2-propanol (0.653 ml), fumaric acid (6.0 mg) was added. The suspension was sonicated and then stirred at 50° C. for 5 minutes. Water (0.0327 ml) was added and stirring was continued at the same temperature. 2-Propanol (0.653 ml) and water (0.0327 ml) were added and stirring was continued at the same temperature. Fumaric acid (6.0 mg) was added, and after stirring at the same temperature to form a solution, the mixture was further stirred overnight at room temperature. The precipitate was collected by filtration under a nitrogen atmosphere. They were then dried under aeration for 2 hours to give the title compound (26.0 mg, 34%) as white powder.

Provenance & Evidence