Maleic Acid → HCID 131730218, compound

Participants

Reaction Conditions

Reaction Steps

After suspending N-(2-fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide (65.3 mg) in acetone (1.306 ml), maleic acid (12.0 mg) was added. The suspension was sonicated and then stirred at 50° C. for 5 minutes to form a solution. The solution was stirred at room temperature for 16 hours and stirred at 4° C. for 4 days. The precipitate was collected by filtration under a nitrogen stream. After washing with acetone (0.020 ml), it was dried under aeration at room temperature for 2 hours to give the title compound (15.1 mg, 20%) as white powder.

Provenance & Evidence