L-Malic Acid → HCID 131730219, compound

Participants

Reaction Conditions

Reaction Steps

N-(2-Fluoro-4-{[2-({[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}amino)pyridin-4-yl]oxy}phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide (31.4 mg) was suspended in ethanol (0.317 ml). (2S)-Malic acid (5.7 mg) was added to the suspension at room temperature, and the mixture was stirred at 50° C. to form a solution. The reaction mixture was stirred at room temperature for 18 hours. The precipitate was collected by filtration and washed with ethanol (0.158 ml, 2 times). It was then dried under aeration at room temperature for 30 minutes, and dried with warm air at 60° C. for 1 day to give the title compound (26.0 mg, 68%) as white crystals.

Provenance & Evidence