Hydrochloric Acid → HCID 131730223, compound

Participants

Reaction Conditions

Reaction Steps

N-{2,5-Difluoro-4-[(2-{[(3-hydroxyazetidin-1-yl)carbonyl]amino}pyridin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide (32.5 mg) was suspended in acetone (0.325 ml). 5N hydrochloric acid (0.012 ml) was added at room temperature. After adding water (0.151 ml), the mixture was heated and stirred at 50° C. for 5 minutes to form a solution. The solution was stirred at room temperature for 30 minutes, acetone (0.325 ml) was added, and stirring was continued for 26 hours. The precipitate was collected by filtration and washed with acetone (0.163 ml, twice). It was then dried under aeration at room temperature for 1 hour and then dried with warm air at 60° C. for 12 hours to give the title compound (27.6 mg, 80%) as white crystals.

Provenance & Evidence