Ethanesulfonic acid → HCID 131730226, compound

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Reaction Steps

N-{2,5-Difluoro-4-[(2-{[(3-hydroxyazetidin-1-yl)carbonyl]amino}pyridin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide (32.5 mg) was suspended in ethanol (0.325 ml). After adding ethanesulfonic acid (0.006 ml) at room temperature to form a solution, it was stirred at room temperature for 25 hours. The precipitate was collected by filtration and washed with ethanol (0.163 ml, 2 times). It was then dried under aeration at room temperature for 1 hour and dried with warm air at 60° C. for 12 hours to give the title compound (25.5 mg, 65%) as white crystals.

Provenance & Evidence