p-Toluenesulfonic acid monohydrate → HCID 131730228, compound

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Reaction Steps

N-{2,5-Difluoro-4-[(2-{[(3-hydroxyazetidin-1-yl)carbonyl]amino}pyridin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide (34.2 mg) was suspended in ethanol (0.342 ml). p-Toluenesulfonic acid monohydrate (13.2 mg) was added at room temperature to form a solution, which was then stirred at room temperature for 90 hours and 25 minutes. Ethanol (1 ml) was added, and the precipitate was collected by filtration and washed with tert-butyl methyl ether (1 ml, three times). It was then dried under aeration at room temperature for 1 hour to give the title compound (33.0 mg, 73%) as white crystals.

Provenance & Evidence