Aminoacetaldehyde dimethyl acetal → HCID 178495894, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-amino-8-benzyl-1-[4-fluoro-4′-(methylsulfonyl)biphenyl-2-yl]-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one (50 mg, 0.10 mmol) in 2,2-dimethoxyethylamine (2.0 ml) was sealed and allowed to stir at 85° C. for 18 h. The temperature was increased to 110° C., and the reaction was allowed to stir for an additional 16 h. The reaction was diluted with EtOAc and washed with brine. The organic portion was dried over sodium sulfate, filtered, and concentrated in vacuo to yield 8-benzyl-4-[(2,2-dimethoxyethyl)amino]-1-[4-fluoro-4′-(methylsulfonyl)biphenyl-2-yl]-7-methyl-1,3,8-triazaspiro[4.5]dec-3-en-2-one. LCMS (M+H) 609.0.

Provenance & Evidence