反应详情

To a solution of 25 g (0.131 mol) of 2-chloro-4-fluoro-5-nitrotoluene in 250 ml of 2-propanol is added 208 g (0.659 mol, 5 eq.) of Cs2CO3. The mixture is stirred at 60° C. overnight and most of the 2-propanol is evaporated under reduced pressure. Water is added and the solution is extracted with EtOAc. The organic layers are combined, dried over MgSO4, concentrated and the crude product filtrated over a silica plug (eluent: 95/5 hexanes/EtOAc) to afford 2-chloro-4-isopropoxy-5-nitrotoluene as a pale yellow fluffy solid.

1. customis evaporated under reduced pressure
2. additionWater is added
3. extractionthe solution is extracted with EtOAc
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. filtrationthe crude product filtrated over a silica plug (eluent: 95/5 hexanes/EtOAc)