HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 388561Generated: October 29, 2026
Methyl iodide → 4-(5-Isopropoxy-2-methyl-4-nitro-phenyl)-1-methyl-pyridinium iodide
https://huagongshe.com/reaction/388561
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 5-Methyl-2-isopropyloxy-4-(pyridine-4-YL)-nitrobenzene | HCID 59764545 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(5-Isopropoxy-2-methyl-4-nitro-phenyl)-1-methyl-pyridinium iodide | HCID 67071170 | — |
Reaction Steps
4-(5-Isopropoxy-2-methyl-4-nitro-phenyl)-pyridine (Example 7, Step 1, 217 mg, 0.797 mmol) is dissolved in anhydrous THF (9 mL). Iodomethane (0.10 mL, 1.61 mmol, 2 equiv.) is added and the reaction is stirred at 40° C. in a sealed tube for 2 days. The volatiles are removed under vacuum generating 4-(5-Isopropoxy-2-methyl-4-nitro-phenyl)-1-methyl-pyridinium iodide as a brown solid: ESMS m/z 287.1 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08377921B2 |
|---|
| Source dataset | uspto-grants-2013_02 |
|---|
| ORD ID | ord-58051922a277400e96ae5809684f1aa8 |
|---|
| Source note | uspto-grants-2013_02 |
|---|
