HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-isopropoxy-2-methyl-4-nitrophenyl)-N,N-dimethylcyclohex-3-enamine → 4-(4-(Dimethylamino)cyclohexyl)-2-isopropoxy-5-methylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-isopropoxy-2-methyl-4-nitrophenyl)-N,N-dimethylcyclohex-3-enamine | HCID 59764470 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(4-(Dimethylamino)cyclohexyl)-2-isopropoxy-5-methylaniline | HCID 59764590 | — |
Reaction Steps
To a solution of 4-(5-isopropoxy-2-methyl-4-nitrophenyl)-N,N-dimethylcyclohex-3-enamine (0.1 mmol) in 10 mL of MeOH, is added Pd/C (5 mg) under argon. The suspension is stirred under 1 atm. H2 for 6 hours. After filtering, solvent is removed and 4-(4-(dimethylamino)cyclohexyl)-2-isopropoxy-5-methylaniline is obtained. MS (ES+): 291.24 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08377921B2 |
| Source dataset | uspto-grants-2013_02 |
| ORD ID | ord-d34caa84a66d479ba238fee106ae99a4 |
| Source note | uspto-grants-2013_02 |