Sulfuric acid magnesium salt (1:1) → HCID 86626294, compound

HRID 388591Notes

Reaction equation

HRID 388591 reaction equation
[Cl:1][C:2]1[C:11]([N+:12]([O-])=O)=[C:10]([NH:15][C@@H:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.S([O-])([O-])(=O)=O.[Mg+2]>>[Cl:1][C:2]1[C:11]([NH2:12])=[C:10]([NH:15][C@@H:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 86626293HCID 86626293, compound

Product 1

HCID 86626294HCID 86626294, compoundYield 96.2%

Procedure

The method of Part B of Example 1 was used to hydrogenate 2-chloro-3-nitro-N-[(1R)-1-phenylethyl]quinolin-4-amine (24.35 g, 73.3 mmol) with the modifications that the reaction was stopped after one hour, and magnesium sulfate was added to the mixture before filtration. 2-Chloro-N4-[(1R)-1-phenylethyl]quinoline-3,4-diamine (21.0 g) was isolated as an amber oil.

Sources & evidence

ORD record
ord-4a6838a5f1ef442088733baf228187ea
Source dataset
uspto-grants-2013_02
Patent number
US08377957B2

Reaction notes

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