反应详情

温度

100 °C

Commercially available chromanone 11a (9.78 g, 66.0 mmol) dissolved in AcOH (20 mL) is added to a suspension of zinc dust (108 g, 1.65 mol) in AcOH (150 mL). The mixture is heated to 100° C. and is stirred mechanically overnight. The mixture is then filtered through Celite® (washed with EtOAc, 100 mL), diluted with PhMe (300 mL) and the solution is evaporated to give chroman intermediate 11b (8.45 g, 95% yield).

1. filtrationThe mixture is then filtered through Celite® (washed with EtOAc, 100 mL)
2. additiondiluted with PhMe (300 mL)
3. customthe solution is evaporated