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N-(2-acetyl-5-methoxyphenyl)-4-Isopropyl-2-Thiazolecarboxamide → N-(6-Acetyl-3-methoxy-2-methylphenyl)-4-(propan-2-yl)-1,3-thiazole-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(2-acetyl-5-methoxyphenyl)-4-Isopropyl-2-Thiazolecarboxamide | HCID 20773655 | — |
| 反応物 | 2'-Amino-3'-methyl-4'-methoxyacetophenone | HCID 25067316 | — |
| 反応物 | 4-(Propan-2-yl)-1,3-thiazole-2-carbonyl chloride | HCID 57578796 | — |
| 生成物 | N-(6-Acetyl-3-methoxy-2-methylphenyl)-4-(propan-2-yl)-1,3-thiazole-2-carboxamide | HCID 53482122 | 66% |
反応手順
N-(6-Acetyl-2-methyl-3-methoxyphenyl)-4-isopropylthiazole-2-carboxamide 217b was synthesized from compound 201b and compound 214 as a beige solid in 66% yield, according to the procedure as described for compound 217a. MS (ESI, EI+): m/z=333 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08377962B2 |
| 出典データセット | uspto-grants-2013_02 |
| ORD ID | ord-7abf62dbf13040bcb124b4d44c4179c2 |
| 出典メモ | uspto-grants-2013_02 |