HRID388663

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(C(C)=O)c(NC(=O)c2nc(C(C)C)cs2)c1

HCID20773655

N-(2-Acetyl-5-methoxyphenyl)-4-(1-methylethyl)-2-thiazolecarboxamide

C16H18N2O3S

HCID29919988

1-(2-Amino-3-chloro-4-methoxyphenyl)ethan-1-one

C9H10ClNO2

HCID57578796

4-(Propan-2-yl)-1,3-thiazole-2-carbonyl chloride

C7H8ClNOS

PRODUCTS

生成物

结构：COc1ccc(C(C)=O)c(NC(=O)c2nc(C(C)C)cs2)c1Cl

HCID56605150

N-(6-Acetyl-2-chloro-3-methoxyphenyl)-4-(propan-2-yl)-1,3-thiazole-2-carboxamide

C16H17ClN2O3S

收率 80%

PROCEDURE

实验过程

N-(6-Acetyl-2-chloro-3-methoxyphenyl)-4-isopropylthiazole-2-carboxamide 217d was synthesized from 1-(2-amino-3-chloro-4-methoxyphenyl)ethanone and compound 214 as a beige solid in 80% yield, according to the procedure as described for compound 217a. 1H NMR (CDCl3, 400 MHz) δ (ppm) 1.47 (s, 3H), 1.48 (s, 3H), 2.57 (s, 3H), 3.34-3.41 (quint, J=6.90 Hz, 1H), 3.98 (s, 3H), 6.86 (d, J=8.48 Hz, 1H), 7.64 (d, J=8.48 Hz, 1H), 8.07 (s, 1H); MS (ESI, EI−) m/z=351 (MH−); MS (ESI, EI+): m/z=353 (MH+).