3-Methyl-2-butanone → HCID 53396467, compound

HRID 388675Notes

Reaction equation

HRID 388675 reaction equation
[CH3:1][CH:2]([CH3:6])[C:3](=[O:5])[CH3:4].C(O[CH:10](OCC)[N:11]([CH3:13])[CH3:12])C>>[CH3:10][N:11]([CH3:13])[CH:12]=[CH:4][C:3](=[O:5])[CH:2]([CH3:6])[CH3:1]

Participants

3

Reactant 2

HCID 112513-Methyl-2-butanoneHCID 70913Dimethylformamide diethylacetal

Product 1

HCID 53396467HCID 53396467, compoundYield 80%

Procedure

3-Methylbutan-2-one (2.5 g, 1 eq.) and dimethylformamide diethylacetal (7.46 mL, 1.5 eq.) were heated at 100° C. for 4 days to give compound 232 as yellow viscous oil in 80% yield., which was used directly without further purification in the next step. 1H NMR (DMSO-d6, 400 MHz) δ (ppm) 0.94 (s, 3H), 0.95 (s, 3H), 2.52 (s, 1H), 2.74 (brs, 3H), 3.01 (brs, 3H), 4.96 (d, J=12.97 Hz, 1H), 7.45 (d, J=12.97 Hz, 1H).

Sources & evidence

ORD record
ord-921f1a1cc6d84aad90af708e6159921f
Source dataset
uspto-grants-2013_02
Patent number
US08377962B2

Reaction notes

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