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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 388692Generated: October 25, 2026

4-(Propan-2-yl)-1,3-thiazole-2-carbonyl chloride → 4-Cyclopropyl-thiazole-2-carbonyl chloride

https://huagongshe.com/reaction/388692

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Propan-2-yl)-1,3-thiazole-2-carbonyl chlorideHCID 57578796—
ReactantLithium 4-cyclopropylthiazole-2-carboxylateHCID 68792487—
Product4-Cyclopropyl-thiazole-2-carbonyl chlorideHCID 59434826—

Reaction Steps

Compound 267a was synthesized from compound 266a (3 g, 1 eq.) as a brown solid in quantitative yield, following the procedure as described for compound 214. MS (ESI, EI+): m/z=170 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08377962B2
Source datasetuspto-grants-2013_02
ORD IDord-23da4ab334aa4f95a30c6ca2c5faed6f
Source noteuspto-grants-2013_02