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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 388693Generated: October 29, 2026

4-(Propan-2-yl)-1,3-thiazole-2-carbonyl chloride → 4-Cyclobutylthiazole-2-carbonyl chloride

https://huagongshe.com/reaction/388693

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Propan-2-yl)-1,3-thiazole-2-carbonyl chlorideHCID 57578796—
ReactantLithium 4-cyclobutylthiazole-2-carboxylateHCID 86646409—
Product4-Cyclobutylthiazole-2-carbonyl chlorideHCID 86646408—

Reaction Steps

4-Cyclobutylthiazole-2-carbonyl chloride 267b was synthesized from compound 266b (5 g, 1 eq.), following the procedure as described for compound 214. MS (ESI, EI+): m/z=198 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08377962B2
Source datasetuspto-grants-2013_02
ORD IDord-eaa1125eb1ab4bc480be308351b37b5f
Source noteuspto-grants-2013_02