HCID 11133098, compound → HCID 15816085, compound

Participants

Reaction Conditions

Reaction Steps

The compound of Example 8E (230 mg, 0.58 mmol) is dissolved in 8 mL of 1 N tetra-n-butylammonium fluoride in tetrahydrofuran and warmed overnight at 80° C. The reaction mixture is partitioned between ether and water; the organic phase was washed with brine and dried over Na2SO4. The solvents were removed in vacuo, and the residue was purified by chromatography on an Analogix Intelliflash 280™, eluting with a gradient of 0% to 50% ethyl acetate in hexanes to isolate the titled compound (140 mg, 85%).

Provenance & Evidence