HCID 68943357, compound → HCID 68673533, compound

Participants

Reaction Conditions

Reaction Steps

The compound of Example 10G (42 mg, 0.093 mmol) was dissolved in 1.5 mL of 1 N tetra-n-butylammonium fluoride in tetrahydrofuran, and warmed overnight at 80° C. The reaction mixture was partitioned between ethyl acetate and water; the organic phase was washed with brine and dried over Na2SO4. The solvents were removed in vacuo, and the residue was purified by chromatography on an Analogix Intelliflash 280™, eluting with a gradient of 0% to 25% ethyl acetate in hexanes to provide the titled compound (27 mg, 86%).

Provenance & Evidence