Methylthiourea → HCID 86620341, compound

HRID 388788Notes

Reaction equation

HRID 388788 reaction equation
Br[CH2:2][C:3]([C:5]1([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:9]=[CH:8][O:7][NH:6]1)=O.[CH3:15][NH:16][C:17]([NH2:19])=[S:18]>C(O)(=O)C>[CH2:13]([O:12][C:10]([C:5]1([C:3]2[N:19]=[C:17]([NH:16][CH3:15])[S:18][CH:2]=2)[CH:9]=[CH:8][O:7][NH:6]1)=[O:11])[CH3:14]

Participants

4

Reactant 2

HCID 2723704MethylthioureaHCID 86620342HCID 86620342, compound

Product 1

HCID 86620341HCID 86620341, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of ethyl 3-(bromoacetyl)isoxazole-3-carboxylate (100 mg, 0.40 mmol) and methylthiourea (69 mg, 0.76 mmol) in acetic acid (3.0 mL) was heated at 150° C. in the microwave for 15 minutes. Solvent was removed in vacuo to give the crude which was used without purification. MF=C10H11N3O3S; LCMS calculated for C10H11N3O3S; (M+H)+: m/z=254.

Workup

  1. customSolvent was removed in vacuo
  2. customto give the crude which
  3. customwas used without purification

Sources & evidence

ORD record
ord-9740b01257e84a49a0a7e9c0fd9630a5
Source dataset
uspto-grants-2013_02
Patent number
US08377976B2

Reaction notes

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