Methanesulfonic Acid → HCID 69444019, compound

Participants

Reaction Steps

To a 500 mL flask equipped with a Dean-Stark trap was added tricyclodecyl methanol (50 g, 300 mmol), acrylic acid (23.8 g, 330 mmol), heptane (250 mL), methanesulfonic acid (3.0 g), and MEHQ (132 mg). The mixture was refluxed for 65 minutes under a mild air sparge, at which point 5.3 mL water (theoretical amount 5.4 mL) had collected in the Dean-Stark trap. The mixture was washed with sodium bicarbonate, dried over magnesium sulfate, and finally passed over silica gel. The solvent was removed by rotary evaporation to afford the product (64.3 g, 97.3% yield).

Provenance & Evidence