2-Aminopyridine → HCID 178497379, compound

HRID 388925Notes

Reaction equation

HRID 388925 reaction equation
[N:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1)=[C:2]=S.NC1C=CC=CN=1.[NH2:17][C:18]1[CH:19]=[C:20]([CH:25]=[CH:26][C:27]=1[NH2:28])[C:21]([O:23][CH3:24])=[O:22]>>[CH3:24][O:23][C:21]([C:20]1[CH:25]=[CH:26][C:27]2[NH:28][C:2]([NH:1][C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=3)=[N:17][C:18]=2[CH:19]=1)=[O:22]

Participants

4

Reactant 3

HCID 104392-AminopyridineHCID 992362-Pyridyl isothiocyanateHCID 1355243,5-Diamino-2-methylbenzoic acid

Product 1

HCID 178497379HCID 178497379, compound

Procedure

2-Isothiocyanatopyridine (4 mmol), prepared from 2-aminopyridine employing general procedure A, was reacted with methyl 3,4-diaminobenzoate as described in general procedure B to afford 2-(pyridin-2-ylamino)-1H-benzimidazole-5-carboxylic acid methyl ester. This ester was hydrolyzed, following general procedure C, to obtain 2-(pyridin-2-ylamino)-1H-benzimidazole-5-carboxylic acid.

Sources & evidence

ORD record
ord-77dc3f63c2a04cecb225cd3f409ad9af
Source dataset
uspto-grants-2013_02
Patent number
US08377983B2

Reaction notes

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