反应详情

温度

100 °C

A stirred solution of the nitro compound (2 mmol) in DMF (4 mL) was added with benzylamine (4 mmol) and contents were heated at 100° C. for 6 h. The reaction mixture was cooled to RT and the contents were poured onto ice cold water with vigorous stirring. The solid formed was collected by filtration, washed with water, and dried in vacuo. The residue obtained was purified on silica gel column chromatography using hexane/EtOAC as eluent to provide the product, benzyl-[5-(1H-indazol-6-yloxy)-2-nitrophenyl]-amine as a yellow solid.

1. temperatureThe reaction mixture was cooled to RT
2. additionthe contents were poured onto ice cold water with vigorous stirring
3. customThe solid formed
4. filtrationwas collected by filtration
5. washwashed with water
6. customdried in vacuo
7. customThe residue obtained
8. customwas purified on silica gel column chromatography